What question did this study set out to answer?

The objective is to explore how glycolysis and the NLRP3 inflammasome interact in cellular energy metabolism and inflammation.

Glycolysis and NLRP3 inflammasome activation in diseases

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This review reveals the connection between glycolytic reprogramming and NLRP3 inflammasome activation, highlighting their roles in inflammation.

The objective is to explore how glycolysis and the NLRP3 inflammasome interact in cellular energy metabolism and inflammation.
Review recent literature on glycolytic enzymes and NLRP3 inflammasome regulation.
Analyze the role of metabolic intermediates in NLRP3 activation across various cell types and diseases.
Synthesize insights into how glycolysis influences inflammasome-related cell death.
Glycolytic reprogramming is a key factor in activating the NLRP3 inflammasome across different diseases.
Specific glycolytic enzymes like HKs and PKM2 play crucial roles in this activation process.
Findings suggest that targeting the glycolysis-NLRP3 axis could lead to novel therapeutic approaches for inflammatory disorders.

Xu et al. (2026) studied this question.

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This review reveals the connection between glycolytic reprogramming and NLRP3 inflammasome activation, highlighting their roles in inflammation.