Reports potent antibacterial activity of clathriamine A isolated from a marine sponge, suggesting potential in drug development.
A novel bis-indole, bis-guanidinium alkaloid, clathriamine A (1), has been isolated from a Western Australian marine sponge, Clathria (Thalysias) sp. (order: Poecilosclerida, family: Microcionidae). The structure of 1 was elucidated via comprehensive NMR analyses as well as TD-DFT predictions of ECD spectra. Biological evaluation against a panel of microorganisms and cell lines revealed potent and selective antibacterial activity for compound 1.
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Sala et al. (2026) studied this question.
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