In vitro chemical isolation demonstrates antimicrobial activity of bis-indole alkaloid myrindole A against bacteria, highlighting marine natural products as prospective antibiotic leads.
Myrindole A, a bis-indole alkaloid, was isolated from the deep-sea sponge Myrmekioderma sp. The high degree of unsaturation of the molecule complicated the assignment of its structure by standard 2D-NMR experiments but was ultimately achieved by a combination of 1 H– 15 N-HMBC and 1, n -ADEQUATE experiments as well as the comparison of measured and calculated CD spectra. Myrindole A showed antimicrobial activity against Gram-positive and Gram-negative bacteria.
No takes yet. Share an insight, caveat, or question.
Moosmann et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: