What question did this study set out to answer?

To isolate and structurally characterize secondary metabolites from the coral-associated fungus Pestalotiopsis microspora GXIMD 02530 and assess their biological activities.

August 14, 2026Marine DrugsOpen Access

Two New Indole Derivatives from the Beibu Gulf Coral-Derived Fungus Pestalotiopsis microspora GXIMD 02530

View Full Paper

Ask AI

Bookmark

Authors

HSHui ShiGuangxi University GYGuihua YangQilu University of Technology XLXiaolin LiuGuangxi University

Discussion

Member takes

Implication

In vitro experimental study uncovers novel indole derivatives from marine fungus, indicating potential templates for anti-inflammatory and antibacterial therapies.

Key Points

To isolate and structurally characterize secondary metabolites from the coral-associated fungus Pestalotiopsis microspora GXIMD 02530 and assess their biological activities.
Extracted fungal metabolites and determined chemical structures and absolute configurations using spectroscopic analysis, electronic circular dichroism (ECD) calculations, single-crystal X-ray diffraction, and chiral chromatography.
Evaluated compounds for anti-inflammatory potential via LPS-induced NF-κB luciferase reporter assays and tested antibacterial activity against Gram-positive bacterial strains.
Characterized two novel indole derivatives (1 and 2), including the rare racemic tricyclic compound furoindolin A (1), along with fourteen known indole and polyketide compounds.
Demonstrated that compounds (±)-1, 3, 4, and 6–12 exhibited inhibitory activity against LPS-induced NF-κB luciferase expression.
Showed phomopsilactone (10) exhibited antibacterial activity against Staphylococcus epidermidis (MIC 15.6 μg/mL), Bacillus subtilis (MIC 31.25 μg/mL), and Staphylococcus aureus (MIC 62.5 μg/mL).

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec7bab70b84ec8b914541 https://doi.org/10.3390/md24080279

View Full Paper

Ask AI

Bookmark

August 14, 2026Marine DrugsOpen Access

Two New Indole Derivatives from the Beibu Gulf Coral-Derived Fungus Pestalotiopsis microspora GXIMD 02530

View Full Paper

Ask AI

Bookmark

Authors

HSHui ShiGuangxi University GYGuihua YangQilu University of Technology XLXiaolin LiuGuangxi University

Discussion

Member takes

Implication

In vitro experimental study uncovers novel indole derivatives from marine fungus, indicating potential templates for anti-inflammatory and antibacterial therapies.

Key Points

To isolate and structurally characterize secondary metabolites from the coral-associated fungus Pestalotiopsis microspora GXIMD 02530 and assess their biological activities.
Extracted fungal metabolites and determined chemical structures and absolute configurations using spectroscopic analysis, electronic circular dichroism (ECD) calculations, single-crystal X-ray diffraction, and chiral chromatography.
Evaluated compounds for anti-inflammatory potential via LPS-induced NF-κB luciferase reporter assays and tested antibacterial activity against Gram-positive bacterial strains.
Characterized two novel indole derivatives (1 and 2), including the rare racemic tricyclic compound furoindolin A (1), along with fourteen known indole and polyketide compounds.
Demonstrated that compounds (±)-1, 3, 4, and 6–12 exhibited inhibitory activity against LPS-induced NF-κB luciferase expression.
Showed phomopsilactone (10) exhibited antibacterial activity against Staphylococcus epidermidis (MIC 15.6 μg/mL), Bacillus subtilis (MIC 31.25 μg/mL), and Staphylococcus aureus (MIC 62.5 μg/mL).

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec7bab70b84ec8b914541 https://doi.org/10.3390/md24080279

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark