BPS2026 – Exploring the diverse states of HER2’s neighbors in breast cancer

Breast cancer is now the most diagnosed cancer in women worldwide. HER2 is a receptor tyrosine kinase that plays a pivotal role in the development and progression of certain aggressive breast cancers. The HER2 receptor can exist in various functional states, including monomers, homodimers, clusters, or heterodimers with other members of the EGFR family. While many studies have focused on the vertical signaling pathways of HER2, its lateral interactions within the membrane remain less clear. In this study, we utilized eosin Y-based multimap proximity labeling proteomics to investigate the membrane protein neighbors of HER2 in different states and different breast cancer subtypes. This approach aims to provide new insights into HER2-associated protein interactions and their functional roles in breast cancer.