CCL27 regulates immune responses and angiogenesis in skin wound healing process

CCL27 is the most skin-specific chemokine predominantly expressed by keratinocytes (Morales et al., 1999). Its only known receptor is CCR10 (Homey et al., 2000, Jarmin et al., 2000). CCL27 was previously reported to help wound repair through promoting migration and growth of CCR10-expressing endothelial cells and keratinocyte stem cells (Bunemann et al., 2018, Inokuma et al., 2006, Kroeze et al., 2012). However, CCL27 could also regulate activation of skin-resident T cells and innate lymphoid cells (ILCs) during wound repair, most of which express CCR10 (Yang et al., 2016). Additionally, a recent study found that endothelial cell CCR10 activation by CCL28, the other ligand of CCR10, impairs skin wound repair under diabetic conditions (Chen et al., 2022). Therefore, roles of CCL27 in wound repair need further clarification. In this study, we provided evidence supporting important roles of CCL27 in restricting over-active inflammatory responses and promoting angiogenesis during skin wound repair using our recently generated CCL27-KO mice (Davila et al., 2022).