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The aim is to investigate the effects of trophoblastic thyrotropin on thyroid function in patients with trophoblastic tumors.

February 21, 2026Mayo Clinic ProceedingsOpen Access

Hyperthyroidism Induced by Trophoblastic Thyrotropin

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The aim is to investigate the effects of trophoblastic thyrotropin on thyroid function in patients with trophoblastic tumors.
Analyzed serum and urine from patients with hydatidiform mole and choriocarcinoma
Characterized trophoblastic thyrotropin compared to pituitary TSH and normal chorionic TSH
Assessed thyroid function in relation to the presence of trophoblastic tumors
Increased thyroid function was observed in 37 patients with trophoblastic tumors.
Clinical hyperthyroidism was found in 13 patients (8 with hydatidiform mole, 5 with choriocarcinoma).
A novel thyroid stimulator with different immunological properties was identified in 20 patients.

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Cases reveal increased thyroid function in trophoblastic tumors, indicating a unique hormone role.

Jerome M. Hershman (1972) studied this question.

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