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February 21, 2026International Journal of Clinical and Health PsychologyOpen Access

Comparative efficacy of tDCS and tACS in the context of enhancing executive function under acute stress: A randomized, sham-controlled study

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Authors

ZGZhihua GuoLYLiu YangYLYushan LiAir Force Medical University

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Implication

Randomized sham-controlled study compares tDCS and tACS effects on executive function during stress.

Key Points

  • The study aims to compare the effectiveness of tDCS and tACS in enhancing executive functions under acute stress.
  • Conducted a randomized, participant-blinded, sham-controlled study.
  • Included 110 healthy male undergraduates aged 18–25.
  • Applied either active tDCS, tACS, or sham stimulation before inducing stress.
  • Assessed executive function via multiple cognitive tasks.
  • Utilized functional near-infrared spectroscopy (fNIRS) to record brain activity.
  • tDCS group showed greater working memory accuracy compared to tACS and sham groups.
  • Both tES techniques improved response inhibition compared to sham.
  • Lower left DLPFC activation was observed during cognitive tasks in both tES groups.
  • tDCS was associated with the lowest DLPFC activation during cognitive inhibition tasks.
  • Elevated activation in the right pre-supplementary motor area was noted during task switching for both tES groups.

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/69994a7f873532290d01ef57https://doi.org/10.1016/j.ijchp.2026.100669
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