Investigation of the effect of latanoprostene bunod and latanoprost on peripapillary optical coherence tomography angiography

Q: What does this research mean for the field?

Latanoprostene bunod (LBN) increases vessel density in peripapillary optical coherence tomography angiography (OCTA) compared to latanoprost (LP), which has no effect on vessel density. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Zeki Baysal; Ömer Faruk Özer; L. Doğan; G. Yildirim Biçer

doi:10.1016/j.jfo.2026.104793

February 17, 2026Journal Français d OphtalmologieOpen Access

Investigation of the effect of latanoprostene bunod and latanoprost on peripapillary optical coherence tomography angiography

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Key Points

The study aims to compare the effects of latanoprostene bunod and latanoprost on vascular density as measured by optical coherence tomography angiography.
Administered latanoprostene bunod and latanoprost once daily.
Measured vascular density in the peripapillary area using optical coherence tomography angiography (OCTA).
Assessed the effect of treatment on intraocular pressure and nitric oxide involvement.
Latanoprostene bunod increased vascular density in the peripapillary region.
Latanoprost had no significant effect on vascular density.
Future research is suggested to explore nitric oxide's role and intraocular pressure reduction in these effects.

Implication

Investigation shows increased vascular density in peripapillary area, indicating potential benefits of latanoprostene bunod.

Abstract

In conclusion, LBN administered once a day increased VD in peripapillary OCTA. LP had no effect on VD. Future studies should be aimed at determining whether this effect of LBN is NO induced or due to higher IOP reduction.

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Cite This Study

Baysal et al. (2026) studied this question.

synapsesocial.com/papers/69994ad4873532290d01f278 https://doi.org/10.1016/j.jfo.2026.104793

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Investigation of the effect of latanoprostene bunod and latanoprost on peripapillary optical coherence tomography angiography

Key Points

Implication

Abstract

Discussion

Cite This Study

Investigation of the effect of latanoprostene bunod and latanoprost on peripapillary optical coherence tomography angiography

Key Points

Implication

Abstract

Discussion

Cite This Study

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