Rescue of mitochondrial power outages with γPNA-based miR-122 inhibitor

MicroRNAs (miRNAs) are crucial post-transcriptional regulators that significantly affect gene expression in metazoans through base pairing with target mRNAs. They can traverse cellular and tissue boundaries via extracellular vesicles or as miRNA-Ago complexes to reach distant organs, thereby exerting substantial influences on miRNA activity in both donor and recipient cells. This phenomenon has been demonstrated in various disease models.1 The role of miR-122, a liver-specific microRNA that is increasingly released by hepatocytes under elevated lipid conditions, has raised concerns about its possible harmful effects on non-hepatic cells.