Novel one-pot annulation reaction yields valuable spiro-pyrazolone-benzoazepines, indicating high efficiency.
A novel one-pot, three-component [4 + 3] annulation reaction of pyrazolone-derived azomethine ylides with N-(2-chloromethyl) aryl amides has been developed. This method provides efficient access to a series of interesting and valuable spiro-pyrazolone-benzo[b]azepines in moderate to excellent yields with high regioselectivity and excellent diastereoselectivity under mild conditions.
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Xu et al. (2026) studied this question.
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