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February 21, 2026CureusOpen Access

Steroid-Resistant Immune Thrombocytopenia With Severe Bleeding Successfully Managed Using Eltrombopag and Mycophenolate in a 67-Year-Old Male

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Authors

AFAbdul Hanan FarooqUniversity Hospitals Bristol NHS Foundation TrustMKMuhammad Badar KhalidUniversity Hospitals Bristol NHS Foundation TrustAMAyesha MuneerSalford Royal NHS Foundation Trust

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Implication

Case report reveals effective management of severe bleeding in an elderly male with steroid-refractory immune thrombocytopenia, suggesting treatment strategies.

Key Points

  • To report the management of a 67-year-old male with steroid-resistant immune thrombocytopenia and severe bleeding.
  • Patient with severe thrombocytopenia and mucocutaneous bleeding evaluated.
  • Bone marrow examination conducted to assess megakaryocytes and exclude secondary causes.
  • Treatment began with corticosteroids, then azathioprine, followed by eltrombopag and mycophenolate.
  • Platelet counts monitored over time to assess treatment response.
  • Platelet count initially remained low despite high-dose corticosteroids.
  • After switching to mycophenolate, platelet count increased to 88 × 10³ per microliter at discharge.
  • Platelet count normalized to over 150 × 10³ per microliter within two weeks, with complete resolution of bleeding.

Cite This Study

Farooq et al. (2026) studied this question.

synapsesocial.com/papers/69994b64873532290d01f96chttps://doi.org/10.7759/cureus.103853
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