Research demonstrates efficient synthesis of griseoviridin intermediate, indicating progress toward total synthesis efforts.
The synthesis of bis-macrolactam 5 as an advanced intermediate for the projected total synthesis of griseoviridin (1) has been achieved via intramolecular Suzuki-Miyaura coupling (>70% yield). Further key steps were the construction of the C(17)-C(18) bond by a SmI₂-mediated Barbier-type coupling, the establishment of the C(18) stereocenter by a diastereoselective Narasaka-Prasad reduction, and an electrophilic sulfur transfer to establish the S(1)-C(2) bond. DMP oxidation of 5 and deprotection gave griseoviridin analog 36 in 32% yield.
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Caso et al. (2026) studied this question.
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