What question did this study set out to answer?

The aim is to explore how Sr2+ doped HA@PCL scaffolds can enhance angiogenesis and osteogenesis by regulating macrophage polarization and alleviating stress.

February 21, 2026Materials Today AdvancesOpen Access

Sr2+ doped HA@PCL scaffold regulating reprogramming of macrophage to enhance osteogenesis and angiogenesis via ameliorating endoplasmic reticulum stress

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Authors

YWYizhou WanTongji Hospital JYJialuo YangHuazhong University of Science and Technology YMYan MaUnion Hospital

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Implication

Demonstrates enhanced vascular and bone regeneration in scaffolds, suggesting a new approach for bone healing.

Key Points

The aim is to explore how Sr2+ doped HA@PCL scaffolds can enhance angiogenesis and osteogenesis by regulating macrophage polarization and alleviating stress.
Constructed Sr2+ doped HA@PCL scaffolds using cryogenic 3D printing.
Conducted in vitro and in vivo experiments to evaluate macrophage polarization and regenerative effects.
Performed RNA sequencing to analyze gene expression related to endoplasmic reticulum stress.
Sr2+ doped scaffolds induced the formation of M2-like macrophages, improving with higher Sr2+ concentration.
Inhibition of the IRE1α-XBP1 signaling pathway was observed, leading to reduced endoplasmic reticulum stress.
Significant enhancement in osteogenesis and angiogenesis was noted in both experimental conditions.

Cite This Study

Wan et al. (2026) studied this question.

synapsesocial.com/papers/69994bdd873532290d01fdcf https://doi.org/10.1016/j.mtadv.2026.100721

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Sr2+ doped HA@PCL scaffold regulating reprogramming of macrophage to enhance osteogenesis and angiogenesis via ameliorating endoplasmic reticulum stress

Discussion

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Implication

Key Points

Cite This Study

Sr2+ doped HA@PCL scaffold regulating reprogramming of macrophage to enhance osteogenesis and angiogenesis via ameliorating endoplasmic reticulum stress

Discussion

Member takes

Implication

Key Points

Cite This Study

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