Abstract: Nitrous oxide has been used worldwide for labor analgesia for over a century. It offers a non-invasive, rapidly acting, and self-administered option for pain and anxiety management. The present investigation examines efficacy, safety, and limitations of nitrous oxide when compared to other labor analgesic modalities, including epidural anesthesia, intravenous opioids, and non-pharmacologic methods. Pharmacologically, nitrous oxide has both analgesic and anxiolytic effects via NMDA receptor inhibition, opioid receptor activation, and GABA-A modulation. While it can be less effective than epidurals in producing complete analgesia, studies demonstrate moderate pain relief, high maternal satisfaction, and preserved mobility. Safety considerations include common, mild adverse effects such as nausea, dizziness, and vomiting, with rare risks of hypoxia, especially when combined with other sedatives or in vitamin B12-deficient patients. Fetal exposure occurs via placental transfer, but it is rapidly cleared, with no consistent evidence of significant neonatal harm. In this regard, data on long-term neurodevelopmental outcomes is limited. Comparative studies suggest that nitrous oxide’s efficacy is like certain opioids but inferior to epidural analgesia, and it offers both patient autonomy and ease of administration. Barriers that prevent broader adoption of nitrous include limited availability in rural settings, equipment costs, and the need for proper scavenging systems. Future research should focus on optimizing delivery systems, exploring long-term neonatal safety, and defining nitrous oxides’s role in multimodal pain management. In summary, nitrous oxide represents a safe, flexible, and patient-centered analgesic option for labor, particularly for individuals who are looking for mobility, self-control, and a less invasive alternative to neuraxial anesthesia. Keywords: nitrous oxide, labor analgesia, maternal satisfaction, multimodal pain managent, pregnancy
Kichili et al. (Sun,) studied this question.