What question did this study set out to answer?

This review aims to articulate the roles and mechanisms of circular RNAs in tumor metabolic reprogramming and their potential clinical applications.

Circular RNAs: Key Regulators of Tumor Metabolic Reprogramming and Clinical Translation

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Review elucidates the role of circular RNAs in tumor metabolism, indicating their potential as biomarkers and therapeutic targets.

This review aims to articulate the roles and mechanisms of circular RNAs in tumor metabolic reprogramming and their potential clinical applications.
Systematic review of literature on circular RNAs and their roles in tumor metabolism
Discussion of mechanisms including miRNA sponging and interactions with metabolic enzymes
Examination of circRNAs as potential biomarkers and therapeutic targets
CircRNAs influence key metabolic pathways by modulating glycolytic enzymes and lipid synthesis regulators.
CircRNAs show promise as diagnostic biomarkers due to their stability and tissue specificity.
Emerging strategies for circRNA modulation include inhibitors, mimics, and nanoparticle delivery systems.

Wu et al. (2026) studied this question.

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