High-affinity nitrogen-doped graphene quantum dots for selective in vivo and ex vivo detection of amyloid-β plaques in an Alzheimer's disease rat model

January 1, 2026RSC AdvancesOpen Access

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Key Points

The research aims to develop a high-affinity method for detecting amyloid-β aggregates in an Alzheimer's disease model.
Utilized nitrogen-doped graphene quantum dots for detection.
Conducted in vivo and ex vivo experiments on a rat model of Alzheimer's disease.
Focused on selective binding to amyloid-β plaques.
Successfully identified amyloid-β plaques in both in vivo and ex vivo settings.
Demonstrated high affinity and specificity for amyloid-β aggregates.
Indicated potential for improved early detection of Alzheimer's disease.

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Demonstrates selective detection of amyloid-β plaques in Alzheimer's disease, suggesting enhanced diagnostic tools.

Early and precise detection of the amyloid-β (Aβ) aggregates is a critical factor in understanding Alzheimer's disease (AD) pathology.

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Bahman et al. (2026) studied this question.

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