What question did this study set out to answer?

The study aims to evaluate the non-inferiority of a preservative-free fixed combination medication for treating primary open-angle glaucoma compared to preserved alternatives.

February 21, 2026Clinical ophthalmologyOpen Access

Assessment of the Effectiveness, Tolerability, and Safety of the Preservative-Free Fixed Combination of Timolol, Dorzolamide, and Brimonidine Compared to Separate Therapies in Patients with Glaucoma, a Randomized Controlled Trial

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Authors

SBSandra BelalcázarFundación Neumológica Colombiana ATAndrea Tornero-JimenezLaboratorios Sophia (Mexico)CMClaudia Mejia-MoralesLaboratorios Sophia (Mexico)

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Implication

Randomized controlled trial assesses effectiveness of preservative-free therapy in glaucoma, suggesting improved patient adherence.

Key Points

The study aims to evaluate the non-inferiority of a preservative-free fixed combination medication for treating primary open-angle glaucoma compared to preserved alternatives.
Phase III randomized controlled trial
80 eyes from 43 patients received either preservative-free or preserved therapy
Follow-up at 2 and 4 weeks, and 2 and 3 months
Intraocular pressure measured at specific times
Mixed-effects model used for analysis.
Mean IOP decreased significantly across all groups over three months
No significant difference in IOP reduction between treatment groups
TDB-FC group had increased conjunctival hyperemia at 2 and 4 weeks
No significant differences in ocular comfort or safety parameters observed.

Cite This Study

Belalcázar et al. (2026) studied this question.

synapsesocial.com/papers/69994c6f873532290d020db3 https://doi.org/10.2147/opth.s580973

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Assessment of the Effectiveness, Tolerability, and Safety of the Preservative-Free Fixed Combination of Timolol, Dorzolamide, and Brimonidine Compared to Separate Therapies in Patients with Glaucoma, a Randomized Controlled Trial

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Key Points

Cite This Study

Assessment of the Effectiveness, Tolerability, and Safety of the Preservative-Free Fixed Combination of Timolol, Dorzolamide, and Brimonidine Compared to Separate Therapies in Patients with Glaucoma, a Randomized Controlled Trial

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Implication

Key Points

Cite This Study

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