What question did this study set out to answer?

The aim is to establish a foundational understanding of chronic disease through a geometry-based model.

February 21, 2026Open Access

The Universal Resonance Model (URM) Foundational Declaration — Version 1.0

Key Result

The Universal Resonance Model proposes a geometry-based ontology of chronic disease where disease behavior is governed by instability geometry and systemic resonance, not molecular defects or static labels.

Key Points

The aim is to establish a foundational understanding of chronic disease through a geometry-based model.
Introduces the Universal Resonance Model (URM) as a conceptual framework.
Describes chronic disease behavior using mathematical principles and key metrics.
Defines the Reset Index to determine therapeutic potential in disease management.
Pathology is characterized as a dynamical instability in multiscale biological systems.
Core ontological and mathematical principles of URM are articulated clearly.
Framework serves as a foundational reference for further developments in chronic disease research.

Limitations

No clinical trial data or quantitative clinical outcomes presented.
The model is theoretical and conceptual without empirical validation in patient populations.
No sample size, demographics, or intervention details are provided.
Findings are not based on experimental or observational clinical research but on a framework for disease dynamics.

Abstract

This document presents the official Foundational Declaration of the Universal Resonance Model (URM), Version 1.0. URM establishes a geometry-based ontology of disease, defining pathology as a dynamical instability regime in a coupled, multiscale biological system. Rather than focusing on molecular identity or organ-specific classification, the model describes chronic disease behaviour through restoring curvature (λ₁), variance (σ²), temporal persistence (ρ(τ)), phase delay (Δτ), and cross-system coupling (κ). The Reset Index (RI) formalizes instability proximity and defines the temporal conditions under which therapeutic leverage is maximal. This declaration articulates the core ontological and mathematical principles of URM in a concise form and serves as the foundational reference document for the broader URM body of work. This document is conceptually expanded in:The Universal Resonance Model (URM): A Foundational Framework for Chronic Disease Dynamics (DOI: https://doi.org/10.5281/zenodo.18698512)

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Cite This Study

Anita Domargård (Thu,) reported a other. The Universal Resonance Model proposes a geometry-based ontology of chronic disease where disease behavior is governed by instability geometry and systemic resonance, not molecular defects or static labels.

synapsesocial.com/papers/69994cb3873532290d02165e https://doi.org/https://doi.org/10.5281/zenodo.18699423

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