What question did this study set out to answer?

Evaluate the incidence of bile leakage after cholecystectomy and identify associated risk factors over time.

February 21, 2026World Journal of SurgeryOpen Access

Incidence, Risk Factors, and Time Trends for Bile Leakage After Cholecystectomy for Gallstone Disease—Results From a Population‐Based Cohort Study

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Population-based cohort study evaluates bile leakage incidence post-cholecystectomy, revealing significant risk factors.

Evaluate the incidence of bile leakage after cholecystectomy and identify associated risk factors over time.
Data from Swedish Registry for Gallstone Surgery from 2006 to 2019
Inclusion of all cholecystectomy patients
Analysis of bile leakage occurrences within 30 days using logistic regression
Bile leakage occurred in 1738 out of 152,413 patients (1.14% incidence)
Increased occurrence of ASA II and III patients undergoing surgery
Rise in emergent cholecystectomies from 27.9% to 43.6%
Surgery for complicated gallstone disease increased from 35.4% to 52.5%

Mirzaei et al. (2026) studied this question.

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