Dynamic Foundations of Disease V extends the Universal Resonance Model (URM) by proposing a systems-level framework in which inflammation functions as a propagation medium for instability across coupled biological subsystems. Rather than treating inflammation as a primary pathology, this work conceptualizes it as a transport mechanism that amplifies, synchronizes, and redistributes local perturbations across immune, neural, metabolic, vascular, and autonomic domains. Within a nonlinear dynamical systems perspective, the paper introduces the concepts of coupling gain, threshold transition, and hysteresis to explain how local disturbances may evolve into systemic instability. The model accounts for multimorbidity, transdiagnostic overlap, and asymmetric recovery trajectories without assuming independent disease origins. This is a conceptual framework paper and does not present new empirical data. It formulates testable predictions concerning cross-system correlation, early-warning indicators (variance and lag-1 autocorrelation), and hysteresis in recovery dynamics. The work provides a theoretical foundation for future empirical investigation into inflammatory propagation and system-level stabilization. Part of the Dynamic Foundations of Disease series, this volume specifies the propagation dynamics that complement prior installments addressing genetic stability architecture, microbiome coupling, and temporal physiological regulation. Version 1.0 – Conceptual systems framework. This work did not receive specific external funding.
Anita Domargård (Thu,) studied this question.