DNA nanostars that self-assemble into core-shell condensate microdroplets

Karuna Skipper; Shelley Wickham

doi:10.1039/d5nh00788g

January 1, 2026Nanoscale Horizons

DNA nanostars that self-assemble into core-shell condensate microdroplets

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Key Points

The study aims to explore the self-assembly of DNA nanostars into core-shell condensate microdroplets for various applications.
Synthesis of DNA nanostars with programmable features.
Investigation of phase-separation properties in different conditions.
Analysis of the stability and structure of formed microdroplets.
Successfully created stable core-shell condensate microdroplets from DNA nanostars.
Demonstrated tunable properties of microdroplets affecting their functionality.
Highlighted the potential for creating synthetic cells and microreactors.

Implication

Demonstrates self-assembly of DNA nanostars into microdroplets, suggesting novel applications in synthetic biology.

Abstract

Phase-separating DNA condensates have a range of potential uses, from synthetic cells microreactors, uniquely combining programmable nanoscale subunits with tuneable microscale properties. However, DNA condensates are inherently unstable, leading to...

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Cite This Study

Skipper et al. (2026) studied this question.

synapsesocial.com/papers/69994d42873532290d021dc1 https://doi.org/10.1039/d5nh00788g

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DNA nanostars that self-assemble into core-shell condensate microdroplets

Key Points

Implication

Abstract

Discussion

Cite This Study

DNA nanostars that self-assemble into core-shell condensate microdroplets

Key Points

Implication

Abstract

Discussion

Cite This Study

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