Why the study?
Preeclampsia shares numerous risk factors with cardiovascular diseases, prompting an assessment of high-sensitivity cardiac troponin I levels during pregnancy to predict preeclampsia occurrence.
Does high-sensitivity cardiac troponin I (hs-cTnI) improve the prediction of preeclampsia in pregnant women?
Population
2245 pregnant women from 4 international prospective cohorts
Comparison
hs-cTnI levels and prediction models incorporating hs-cTnI vs models without hs-cTnI
Design
Prospective cohort study
Authors
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hs-cTnI may refine preeclampsia prediction models; hypothesis-generating and requires prospective validation before practice change.
Does high-sensitivity cardiac troponin I (hs-cTnI) improve the prediction of preeclampsia in pregnant women?
High-sensitivity cardiac troponin I enhances the prediction of preeclampsia when added to maternal factors and the sFlt-1/PlGF ratio.
Bacmeister et al. (2023) studied this question.
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