Loss of CD138 expression in multiple myeloma: a rare diagnostic challenge | Synapse
February 22, 2026
Loss of CD138 expression in multiple myeloma: a rare diagnostic challenge
Key Points
To address the diagnostic challenges presented by the absence of CD138 expression in multiple myeloma.
Analysis of CD138 expression levels in multiple myeloma cases.
Identification of diagnostic misclassification risks.
Review of clinical significance of CD138 as a plasma cell marker.
Absence of CD138 in plasma cell myeloma is rare.
This absence can lead to diagnostic misclassification.
The findings emphasize the need for careful interpretation of plasma cell markers.
Abstract
Background: CD138 is a defining plasma cell marker. Absent CD138 expression in plasma cell myeloma is rare and presents a significant diagnostic challenge posing a risk of misclassification.