Loss of CD138 expression in multiple myeloma: a rare diagnostic challenge

Elise Kempler; Roman Pillay; Selina Campion; Georgia McCaughan; Michael Krigstein

doi:10.1016/j.pathol.2026.01.263

February 1, 2026Pathology

Loss of CD138 expression in multiple myeloma: a rare diagnostic challenge

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Key Points

To address the diagnostic challenges presented by the absence of CD138 expression in multiple myeloma.
Analysis of CD138 expression levels in multiple myeloma cases.
Identification of diagnostic misclassification risks.
Review of clinical significance of CD138 as a plasma cell marker.
Absence of CD138 in plasma cell myeloma is rare.
This absence can lead to diagnostic misclassification.
The findings emphasize the need for careful interpretation of plasma cell markers.

Implication

This report highlights absent CD138 expression in multiple myeloma, suggesting a potential risk of misclassification.

Abstract

Background: CD138 is a defining plasma cell marker. Absent CD138 expression in plasma cell myeloma is rare and presents a significant diagnostic challenge posing a risk of misclassification.

Discussion

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Cite This Study

Kempler et al. (2026) studied this question.

synapsesocial.com/papers/699a534bfdaf4e3c1268ee28 https://doi.org/10.1016/j.pathol.2026.01.263

View at Publisher

Ask AI

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Loss of CD138 expression in multiple myeloma: a rare diagnostic challenge

Key Points

Implication

Abstract

Discussion

Cite This Study

Loss of CD138 expression in multiple myeloma: a rare diagnostic challenge

Key Points

Implication

Abstract

Discussion

Cite This Study

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