Observational signals abnormal acylcarnitine in newborns with sertraline exposure, indicating potential metabolic concerns.
Background: Multiple acyl-coenzyme A dehydrogenase deficiency (MADD) is an inborn error of metabolism affecting fatty acid oxidation and is included in newborn screening. Recent reports describe adults with clinical and biochemical features of MADD, but negative genetic findings, associated with sertraline use.
No takes yet. Share an insight, caveat, or question.
Coffey et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: