Serum neurofilament light chain as a biomarker of disease activity in antibody-mediated autoimmune encephalitis

February 1, 2026Pathology

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Key Points

The research aims to evaluate serum neurofilament light chain as a potential biomarker for disease activity in autoimmune encephalitis.
Assess serum neurofilament light levels in patients with autoimmune encephalitis.
Analyze the correlation between serum neurofilament light levels and disease activity.
Focus on patients with cell surface antibody-mediated autoimmune encephalitides.
Serum neurofilament light levels correlate with disease activity in autoimmune encephalitis.
Higher levels of serum neurofilament light are associated with increased disease severity.

Observational study reveals serum neurofilament light predicts disease activity in autoimmune encephalitis, indicating its potential as a biomarker.

Aim: To assess the utility of serum neurofilament light (sNfL) in cell surface antibody-mediated autoimmune encephalitides (AE).

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Kakar et al. (2026) studied this question.

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