Case highlights the potential of salivary cortisone for improving diagnostic accuracy in Cushing's syndrome, indicating the role of salivary glands.
Background: Late-night salivary cortisol (LNSC) is widely used to screen for Cushing’s syndrome, but false positives can occur. Paired salivary cortisone, generated via 11β-HSD2 in salivary glands, may offer a more robust index of endogenous glucocorticoid exposure and help explain discordant results.
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Yau et al. (2026) studied this question.
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