A case of large-burden hepatic amyloidosis complicated by multiple fragility fractures in a young male

Amyloid fibrils represent a heterogenous group of misfolded proteins with a shared pathophysiology resulting in beta-sheets that are inherently resistant to proteolysis and share a typical microscopic appearance. 1–3 Amyloidosis is a condition which arises from the pathological infiltration of amyloid fibrils. 2 Light chain amyloidosis (AL amyloidosis) is one of the most common forms of systemic amyloidosis and arises from abnormal clonal plasma cells. 2 Prognosis of AL amyloidosis is traditionally linked to the extent of cardiac or renal infiltration; however, any organ can be affected, resulting in deleterious outcomes irrespective of established staging algorithms. 2