Massively parallel sequencing reveals B-cell abnormalities in salivary glands and blood of Sjögren’s disease patients, suggesting links to lymphomas.
Background: Sjögren’s disease (SjD) is a chronic autoimmune disease typified by the lymphocytic infiltration of salivary glands (SGs). The SGs are hypothesised to be a reservoir for autoreactive B-cells that clonally expand and transform into lymphomas. We therefore aimed to compare the B-cell repertoire in paired SGs and peripheral blood (PB) from patients with SjD and controls.
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Lee et al. (2026) studied this question.
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