Massively parallel sequencing of B-cell receptors in Sjögren’s disease salivary glands

Key Points

• To compare B-cell repertoire in salivary glands and peripheral blood of Sjögren’s disease patients and controls.
• Utilized massively parallel sequencing to analyze B-cell receptors.
• Collected and compared samples from salivary glands and peripheral blood of patients with Sjögren’s disease and controls.
• Evaluated lymphocytic infiltration in salivary glands.
• Identified distinct B-cell repertoire in salivary glands compared to peripheral blood.
• Found evidence of clonally expanded autoreactive B-cells in Sjögren’s disease patients.
• Highlighted potential link between B-cell abnormalities and lymphomas.