Case report shows metastatic behaviour of neuroendocrine differentiation in pulmonary nodules, implying potential risks.
Composite haemangioendothelioma (CHE) is a rare, locally aggressive vascular neoplasm composed of histologically distinct components. The neuroendocrine subtype carries a higher risk of metastatic behaviour. CHE commonly arises in distal extremities, with pulmonary metastases described but rarely presenting as the initial site of disease.
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Sim et al. (2026) studied this question.
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