Histopathological analysis reveals immune-mediated damage in Acanthamoeba keratitis, emphasizing early diagnosis and treatment.
AK demonstrates marked variability in both organism distribution and host inflammatory response. Tissue damage appears to be more immune-mediated than organism load-dependent. Younger patients tended to show diffuse stromal involvement. Persistent cyst formation underlies recurrence, underscoring the importance of early diagnosis and prolonged postoperative anti-amoebic therapy.
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Mandal et al. (2026) studied this question.
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