Systematic Review of Late Dental Effects Following Head and Neck Radiation Therapy in Childhood Cancer Survivors

Koen B. Krommenhoek; Emma Foster-Thomas; A. Davey; Lucy Davies; Nanouschka H. Maagdenberg; Frances Charlwood; Simona Gaito; Love Goyal; Callum Gillies; Olga Slater; Bernadette Brennan; Mark N. Gaze; Cynthia L. Eccles; A.G. Becking; Johannes HM Merks; Henry Mandeville; Daniel J. Indelicato; Matthew Krasin; Shermaine Pan; Marianne Aznar; M. Hol

doi:10.1016/j.prro.2025.12.011

Key Points

The central aim is to evaluate late dental adverse effects in survivors of childhood head and neck cancer due to radiation therapy.
Conducted a systematic review of existing literature
Analyzed definitions and grading criteria for dental adverse effects
Examined reporting methods related to radiation therapy and dental health
Identified significant gaps in standardization of dental adverse effects reporting
Highlighted the importance of documenting pretreatment dental status
Emphasized the need for improved survivor care practices through better assessment methods

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Implication

This systematic review highlights the need for standardized criteria for assessing late dental effects in childhood cancer survivors, implying better care practices.

Abstract

There is a clear need for standardized definitions, assessment methods, grading criteria, and data reporting for late dental AEs in childhood head and/or neck cancer survivors. Accurate documentation of RT regimens and pretreatment dental status is essential to support dose minimization strategies, tailored patient education, and long-term dental follow-up, ultimately improving survivorship care.

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Krommenhoek et al. (2026) studied this question.

synapsesocial.com/papers/699a9cc6482488d673cd2836 https://doi.org/10.1016/j.prro.2025.12.011

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Systematic Review of Late Dental Effects Following Head and Neck Radiation Therapy in Childhood Cancer Survivors

Key Points

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Implication

Abstract

Discussion

Cite This Study

Systematic Review of Late Dental Effects Following Head and Neck Radiation Therapy in Childhood Cancer Survivors

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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