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February 22, 2026Journal of Medicinal ChemistryOpen Access

Antiviral Profiling and Cellular Activation of Carbobicyclic Nucleoside Analogues

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Authors

SSStephan ScheeffChinese University of Hong KongJBJoan Marie Javillo BaguioChinese University of Hong KongBLBenny Zhibin LiangChinese University of Hong Kong

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Implication

Investigates antiviral effects of new nucleoside analogues in vitro, indicating potential for new therapies.

Key Points

  • The goal is to evaluate the antiviral activity of a new class of nucleoside analogues designed as mimics of ribose.
  • Screened nucleoside analogues for antiviral activity against various viruses
  • Performed structure-activity relationship (SAR) studies
  • Conducted minigenome assays and in silico modeling
  • Evaluated metabolism of triphosphate metabolites
  • Nucleoside analogues exhibited pan-antiviral activity against HCV, HSV, and influenza
  • The uracil analogue 2a significantly inhibited influenza A virus replication
  • C5'-OH groups were phosphorylated without needing prodrug formulations
  • Resulting triphosphate metabolites were not substrates for human DNA/RNA polymerases

Cite This Study

Scheeff et al. (2026) studied this question.

synapsesocial.com/papers/699a9d27482488d673cd2dcdhttps://doi.org/10.1021/acs.jmedchem.5c02584
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