What question did this study set out to answer?

The aim is to evaluate cytokine profiles in children with pHLH and MAS, and to explore correlations with laboratory parameters.

February 22, 2026Journal of Interferon & Cytokine Research

Cytokine Profiles in Children with Primary Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome

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The aim is to evaluate cytokine profiles in children with pHLH and MAS, and to explore correlations with laboratory parameters.
Enrolled 10 pHLH patients and 10 MAS patients for comparison.
Measured serum cytokine levels including IL-6, IL-10, and IL-18.
Compared results with age-matched controls.
IL-10 and IL-18 were significantly elevated in pHLH patients.
IL-8 levels were significantly lower in pHLH compared to controls.
In MAS, IL-18, IL-10, and IL-6 were the most significantly elevated cytokines.

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Implication

Assesses cytokine levels in children with hemophagocytic lymphohistiocytosis and macrophage activation syndrome, suggesting potential biomarkers for these conditions.

Cite This Study

Arun et al. (2026) studied this question.

synapsesocial.com/papers/699a9d27482488d673cd2e19 https://doi.org/10.1177/10799907261422842

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Implication

Assesses cytokine levels in children with hemophagocytic lymphohistiocytosis and macrophage activation syndrome, suggesting potential biomarkers for these conditions.

Cytokine Profiles in Children with Primary Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome

Key Points

Discussion

Implication

Cite This Study

Cytokine Profiles in Children with Primary Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome

Key Points

Discussion

Implication

Cite This Study

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