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February 1, 2026HLA

Description of the Novel HLA‐DQB1*03:03:31 Allele, Identified in a Chinese Individual

Zhan‐Rou Quan J. Liu Bing‐Na Yang Jia‐Min Song H.‐Y. Zou

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Key Points

To describe the novel HLA-DQB1*03:03:31 allele and its genetic differences from HLA-DQB1*03:03:02:02.
Identification of novel allele
Genetic sequencing
Comparison with existing alleles
The novel allele differs by one synonymous nucleotide substitution
The substitution occurs in exon 2
Illustrates genetic variation within the HLA region

Implication

Novel allele HLA-DQB1*03:03:31 shows a nucleotide change in a Chinese individual, indicating genetic diversity.

Abstract

The novel allele HLA‐DQB1*03:03:31 differs from DQB1*03:03:02:02 by one synonymous nucleotide substitution in exon 2.

Discussion

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Cite This Study

Quan et al. (2026) studied this question.

synapsesocial.com/papers/699a9d27482488d673cd2eb4 https://doi.org/10.1111/tan.70610

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Characterisation of the Novel <i>HLA‐DQB1*03:03:37</i> Allele by Next Generation SequencingOriginal Research · 2026 · 2 citations
2The Novel <i>HLA‐C*03:03:77</i> Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese IndividualOriginal Research · 2026 · 1 citations
3The Novel <i>HLA‐C*03:03:75</i> Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese IndividualOriginal Research · 2026 · 1 citations
4Characterisation of the Novel <i>HLA‐DQA1*03:02:05</i> Allele by Next‐Generation Sequencing2025 · 2 citations
5Identification of the Novel Allele, <i>HLA‐DQB1*03:577</i> , by Next‐Generation Sequencing2025

Characterisation of the Novel <i>HLA‐DQB1*03:609</i> Allele by Next Generation Sequencing2026
Characterisation of the Novel <i>HLA‐DQB1*06:03:58</i> Allele by Next‐Generation Sequencing2026
Identification of the Novel <i>HLA‐DQB1*03:03:38</i> Allele Using <scp>PolyseqOne</scp> Nanopore Sequencing Technology2026
Identification of the Novel HLA‐B*35:670 Allele by Next‐Generation Sequencing in a Bone Marrow DonorHLA · 2026
Description of the Novel HLA‐C*06:414 Allele in a Bone Marrow DonorHLA · 2026

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