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February 22, 2026Gut MicrobesOpen Access

Orchestrating life’s first community: molecular assembly by human milk oligosaccharides

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Authors

YZYe ZhouBYBo YangJZJianxin Zhao

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Overview

This review synthesizes mechanisms of HMO-driven microbial assembly in infants, highlighting potential interventions.

Key Points

  • The review aims to uncover how human milk oligosaccharides influence the infant gut microbiota through molecular mechanisms.
  • Synthesized current mechanistic evidence on HMO metabolism in microbial assembly
  • Explored enzymes that provide competitive advantages in microbial environments
  • Distinguished effects of HMO substrates versus intact HMOs in host-microbe signaling
  • Identified specific molecular mechanisms by which HMOs govern microbial competition
  • Reported evidence on the role of HMO breakdown in metabolic networks
  • Highlighted areas where evidence is associative compared to causal in HMO effects

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/699a9d50482488d673cd31f8https://doi.org/10.1080/19490976.2026.2632973
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