Prospective Head-to-Head Comparison of ¹⁸ F-FDG and ⁶⁸ Ga-FAPI PET/CT in De Novo and Recurrent Epstein-Barr Virus–associated Nasopharyngeal Carcinoma

Bingxin Gu; Shuyi Lin; Liyan Bai; Chaosu Hu; Xiaomin Ou; Zhongyi Yang; Shaoli Song

doi:10.1148/rycan.250437

February 20, 2026Radiology Imaging CancerOpen Access

Prospective Head-to-Head Comparison of ¹⁸ F-FDG and ⁶⁸ Ga-FAPI PET/CT in De Novo and Recurrent Epstein-Barr Virus–associated Nasopharyngeal Carcinoma

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Key Points

To compare the effectiveness of Ga-FAPI PET/CT and FDG PET/CT in evaluating nasopharyngeal carcinoma.
Conducted a head-to-head comparison of two PET/CT imaging techniques
Evaluated both methods in de novo and recurrent nasopharyngeal carcinoma cases
Compared outcomes with conventional methods like MRI and plasma Epstein-Barr virus DNA levels
Ga-FAPI PET/CT showed superior performance in initial evaluation and monitoring of recurrence
Outperformed traditional methods for diagnosing nasopharyngeal carcinoma
Suggests Ga-FAPI PET/CT might be more useful in clinical settings.

Implication

Comparison finds Ga-FAPI PET/CT outperforms FDG PET/CT in evaluating nasopharyngeal carcinoma, suggesting clinical benefits.

Abstract

Gallium 68 fibroblast activation protein inhibitor PET/CT outperformed conventional methods (plasma Epstein-Barr virus DNA level, contrast-enhanced MRI/CT, and fluorine 18 fluorodeoxyglucose PET/CT) in nasopharyngeal carcinoma primary evaluation and recurrence monitoring, suggesting its potential clinical utility.

Discussion

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Cite This Study

Gu et al. (2026) studied this question.

synapsesocial.com/papers/699a9d65482488d673cd3341 https://doi.org/10.1148/rycan.250437

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Prospective Head-to-Head Comparison of ¹⁸ F-FDG and ⁶⁸ Ga-FAPI PET/CT in De Novo and Recurrent Epstein-Barr Virus–associated Nasopharyngeal Carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Prospective Head-to-Head Comparison of ¹⁸ F-FDG and ⁶⁸ Ga-FAPI PET/CT in De Novo and Recurrent Epstein-Barr Virus–associated Nasopharyngeal Carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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