What question did this study set out to answer?

To compare the effectiveness of Ga-FAPI PET/CT and FDG PET/CT in evaluating nasopharyngeal carcinoma.

February 22, 2026Radiology Imaging Cancer1 citationsOpen Access

Prospective Head-to-Head Comparison of 18 F-FDG and 68 Ga-FAPI PET/CT in De Novo and Recurrent Epstein-Barr Virus–associated Nasopharyngeal Carcinoma

BGBingxin GuShanghai Medical College of Fudan University SLShuyi LinFudan University LBLiyan BaiShanghai Medical College of Fudan University

Key Points

To compare the effectiveness of Ga-FAPI PET/CT and FDG PET/CT in evaluating nasopharyngeal carcinoma.
Conducted a head-to-head comparison of two PET/CT imaging techniques
Evaluated both methods in de novo and recurrent nasopharyngeal carcinoma cases
Compared outcomes with conventional methods like MRI and plasma Epstein-Barr virus DNA levels
Ga-FAPI PET/CT showed superior performance in initial evaluation and monitoring of recurrence
Outperformed traditional methods for diagnosing nasopharyngeal carcinoma
Suggests Ga-FAPI PET/CT might be more useful in clinical settings.

Abstract

Gallium 68 fibroblast activation protein inhibitor PET/CT outperformed conventional methods (plasma Epstein-Barr virus DNA level, contrast-enhanced MRI/CT, and fluorine 18 fluorodeoxyglucose PET/CT) in nasopharyngeal carcinoma primary evaluation and recurrence monitoring, suggesting its potential clinical utility.

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