Comparative analysis shows 18F-FAPI-42 detects distant metastases in NPC, suggesting enhanced visualization for certain types.
While standalone PET shows differing profiles, integrated 18F‑FAPI‑42 and 18F‑FDG PET/CT provide comparable and high overall accuracy for detecting NPC distant metastases. 18F‑FAPI‑42 offers advantages in visualizing bone and pleural metastases. High false-positive rates for both tracers necessitate careful interpretation with CT correlation. Advanced N-stage is a key predictor of metastatic disease.
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Zheng et al. (2026) studied this question.
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