Integrated ESR and PLT ‐ H Measurement Using the BC ‐6800 Plus Hematology Analyzer: A Comprehensive Analytical Evaluation

Background Complete blood count (CBC) and erythrocyte sedimentation rate (ESR) are essential tests in clinical practice. The Mindray BC‐6800 Plus integrates CBC and ESR analysis through its Easy‐W ESR module and a hybrid platelet channel (PLT‐H) designed to improve platelet quantification, especially under interference. Methods A prospective analytical study was conducted following CLSI guidelines (EP05‐A3, EP06‐A, EP09c). A total of 460 venous samples were analyzed across multiple modes (Auto, Open‐Vial, Predilute). PLT‐H was compared with PLT‐O and reference values; ESR with the BC‐760CS, which shares the same ESR module validated against Westergren. Interference testing included samples with low MCV (< 75 fL) and high MPV (> 10 fL). Results PLT‐H background was consistently < 5 × 10 9 /L. Precision met predefined limits (CV ≤ 4% whole blood, ≤ 8% predilute; ESR SD ≤ 2 mm/h at ≤ 20 mm/h, CV ≤ 10% at > 20 mm/h). Carryover was ≤ 0.2%. PLT‐H showed excellent linearity to 5000 × 10 9 /L ( r = 0.999) and tighter bias distribution than PLT‐O. Agreement was strong for ESR between BC‐6800 Plus and BC‐760CS ( r = 0.989) and for PLT‐H versus PLT‐O ( r = 0.992). PLT‐H maintained robustness in interference‐prone samples ( r = 0.992). Conclusion The BC‐6800 Plus demonstrated excellent analytical performance for ESR and PLT‐H, delivering accurate, reproducible, and interference‐resistant results. It supports efficient, high‐quality testing in modern laboratories.