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February 22, 2026JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY

Impact of Pharmacist‐Led Antimicrobial Stewardship on Antibiotic Use in Intensive Care: A Prospective Audit and Feedback Approach

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Authors

BEBüşra ErgenMarmara UniversityLDLütfiye Mülazımoğlu DurmuşoğluTTTekin TunçelMarmara University

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Implication

Prospective audit finds improved antibiotic use and lower mortality in intensive care with pharmacist involvement, suggesting better patient outcomes.

Key Points

  • This research aims to assess the impact of a pharmacist-led antimicrobial stewardship program on antibiotic use and patient outcomes in intensive care units.
  • Prospective observational study design conducted in an ICU for 6 months with pre- and post-ASP periods.
  • Involved a clinical pharmacist and interprofessional team performing audit and feedback on antimicrobial use.
  • Primary evaluation focused on antimicrobial appropriateness, with secondary measures including consumption and 30-day mortality rates.
  • Antimicrobial appropriateness improved significantly, with inappropriateness dropping from 81.7% to 8.7%.
  • Overall antimicrobial exposure decreased with total days of therapy and length of therapy dropping by 8.5% and 19.5%, respectively.
  • Thirty-day mortality decreased from 56.0% to 38.8%, indicating a significant reduction associated with pharmacist interventions.

Cite This Study

Ergen et al. (2026) studied this question.

synapsesocial.com/papers/699a9d65482488d673cd348dhttps://doi.org/10.1002/jac5.70192
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Also Consider

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  1. 1The Relationship between Antimicrobial Resistance and Patient Outcomes: Mortality, Length of Hospital Stay, and Health Care Costs2005 · 1,298 citations
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  4. 4Measuring Appropriate Antimicrobial Use: Attempts at Opening the Black Box2016 · 176 citations
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