PROTAC-Mediated Multi-Target Protein Degradation in Alzheimer’s Disease: Mechanistic Insights, Therapeutic Applications, and Translational Challenges

Yunan Li; Bin Wang; Tingting Yao; Xinai Shen; Huan Li; Wei Jiang; xinuo Li; Zheying Zhu

doi:10.1039/d5md00963d

January 1, 2026RSC Medicinal ChemistryOpen Access

PROTAC-Mediated Multi-Target Protein Degradation in Alzheimer’s Disease: Mechanistic Insights, Therapeutic Applications, and Translational Challenges

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Key Points

The aim is to explore how Protac technology can target and degrade neurotoxic proteins involved in Alzheimer’s disease.
Analysis of the mechanisms underlying protein degradation via Protacs.
Evaluation of therapeutic applications for Alzheimer’s treatment.
Discussion on the translational challenges faced in clinical settings.
Demonstrated that Protac can efficiently reduce levels of neurotoxic proteins.
Highlighted potential benefits of multi-target approaches over traditional therapies.
Identified significant barriers to successful clinical translation of these therapies.

Implication

Mechanistic insights reveal multi-target protein degradation's potential in Alzheimer's disease, indicating new therapy avenues.

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by multiple interacting pathological mechanisms. Among these, the core driving factor is the accumulation of abnormally folded, neurotoxic proteins. Current therapeutic...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/699a9d8e482488d673cd37ab https://doi.org/10.1039/d5md00963d

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PROTAC-Mediated Multi-Target Protein Degradation in Alzheimer’s Disease: Mechanistic Insights, Therapeutic Applications, and Translational Challenges

Key Points

Implication

Abstract

Discussion

Cite This Study

PROTAC-Mediated Multi-Target Protein Degradation in Alzheimer’s Disease: Mechanistic Insights, Therapeutic Applications, and Translational Challenges

Key Points

Implication

Abstract

Discussion

Cite This Study

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