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February 22, 2026Clinical Cancer Research

Abstract PS2-10-18: Epithelial-mesenchymal transition (EMT) Signature Score of a Bulk Tumor May Not Reflect the EMT of Malignant Epithelial Cells

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Authors

YTYoshihisa TokumaruGifu University HospitalRWR. WuTokyo Medical UniversityMOM. OshiRoswell Park Comprehensive Cancer Center

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Overview

Analysis reveals that EMT scores do not correlate with aggressive tumor features or survival outcomes.

Key Points

  • This research aims to examine whether high EMT scores in breast cancer are linked to aggressive characteristics and poor outcomes.
  • Analyzed three large breast cancer cohorts: TCGA, METABRIC, and SCAN-B.
  • Assessed survival outcomes and tumor immune microenvironment using various metrics.
  • Evaluated chemosensitivity across four independent datasets.
  • Applied single-sample GSEA to single-cell RNA-seq data to investigate EMT signatures.
  • High EMT tumors showed significantly lower Nottingham histological grade and were associated with less cell proliferation.
  • No association was found between high EMT scores and metastasis or survival outcomes in the studied cohorts.
  • High EMT tumors displayed greater infiltration of stromal cells, particularly cancer-associated fibroblasts.

Cite This Study

Tokumaru et al. (2026) studied this question.

synapsesocial.com/papers/699a9da0482488d673cd38dchttps://doi.org/10.1158/1557-3265.sabcs25-ps2-10-18
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract PS4-02-14: Recognition of immunogenomic signature and prognostic value of the subtype of epithelial-mesenchymal transition in breast cancer2026
  2. 2Abstract PS4-02-13: Genes from epithelial-mesenchymal transition predict overall survival effectively in breast cancer: anovel risk model based on initial step of tumor metastasis2026
  3. 3Data from Stromal Signals Dominate Gene Expression Signature Scores That Aim to Describe Cancer Cell–intrinsic Stemness or Mesenchymality Characteristics2024
  4. 4Stromal Signals Dominate Gene Expression Signature Scores That Aim to Describe Cancer Cell–intrinsic Stemness or Mesenchymality Characteristics2024 · 12 citations
  5. 5Decoding the Molecular Drivers of Epithelial to Mesenchymal Transition in Breast Cancer: Insights into Epithelial Plasticity and Microenvironment Crosstalk2026 · 2 citations