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February 22, 2026Clinical Cancer Research

Abstract PS5-10-04: Willingness to participate in a trial comparing standard genetic counseling versus genetic counseling with personalized cancer risk estimates in patients with Li-Fraumeni syndrome

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Authors

AWA. H. WoodsonJCJ. L. CorredorJVJ. Voller

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Overview

Trial participants express willingness for personalized genetic counseling over standard methods in Li-Fraumeni Syndrome, suggesting implications for future research.

Key Points

  • The aim is to assess patient willingness to participate in a trial comparing standard genetic counseling to personalized genetic counseling based on a new risk model.
  • Targeted individuals aged 15 and older who underwent genetic counseling for TP53 testing
  • Distributed a questionnaire via secure email to gather clinical characteristics and participation interest
  • Compared standard genetic counseling with personalized approaches informed by LFSPRO data
  • Questionnaire return rate was 17.9% (65 out of 364 invited)
  • 81.5% of respondents expressed strong interest in participating in the trial
  • 76.9% preferred personalized genetic counseling over standard methods
  • 66.2% felt comfortable with random assignment in the trial

Cite This Study

Woodson et al. (2026) studied this question.

synapsesocial.com/papers/699a9da0482488d673cd39cchttps://doi.org/10.1158/1557-3265.sabcs25-ps5-10-04
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Performance of LFSPRO TP53 germline carrier risk predictions compared to standard genetic counseling practice on prospectively collected probands2024
  2. 2Abstract B039: Exploring the early genetic determinants of tumor risk in Li-Fraumeni Syndrome2025
  3. 3Abstract LB211: Performance of longitudinal cancer screening in Li-Fraumeni syndrome2026
  4. 4Abstract PS3-02-29: Reevaluation of Hereditary Cancer Screening and Testing at an Urban Breast Cancer Survivorship Program in the Bronx, NY - A Pilot Study2026
  5. 5Abstract 6342: Performance of longitudinal cancer screening in Li-Fraumeni syndrome2026