What question did this study set out to answer?

To evaluate the impact of estrogen receptor expression subgroups on patient characteristics, treatment patterns, and overall survival in HER2-negative breast cancer.

February 22, 2026Clinical Cancer Research

Abstract PS3-07-29: Real-world outcomes by Estrogen Receptor Expression Subgroups in Patients with HER2-negative Breast Cancer: A Population-based Cohort Study

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To evaluate the impact of estrogen receptor expression subgroups on patient characteristics, treatment patterns, and overall survival in HER2-negative breast cancer.
Conducted a nationwide cohort study in Sweden from 2007 to 2023
Stratified HER2-negative breast cancer patients by estrogen receptor status into five groups
Analyzed overall survival using Kaplan-Meier and Cox proportional hazards models, adjusting for various factors.
Analyzed 75,473 patients: 70,159 in adjuvant and 5,314 in neo-adjuvant settings
ER-sublow patients had significantly worse overall survival compared to higher ER groups
In multivariable analysis, ER-med also showed poorer survival versus ER-high, but ER-zero and ER-low had similar outcomes to ER-sublow.

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Implication

Population-based cohort study shows ER subgroups impact overall survival in HER2-negative breast cancer, suggesting clinical implications.

Cite This Study

yang et al. (2026) studied this question.

synapsesocial.com/papers/699a9dc0482488d673cd3e0c https://doi.org/10.1158/1557-3265.sabcs25-ps3-07-29

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Implication

Population-based cohort study shows ER subgroups impact overall survival in HER2-negative breast cancer, suggesting clinical implications.

Abstract PS3-07-29: Real-world outcomes by Estrogen Receptor Expression Subgroups in Patients with HER2-negative Breast Cancer: A Population-based Cohort Study

Key Points

Discussion

Implication

Cite This Study

Abstract PS3-07-29: Real-world outcomes by Estrogen Receptor Expression Subgroups in Patients with HER2-negative Breast Cancer: A Population-based Cohort Study

Key Points

Discussion

Implication

Cite This Study

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