Key result
Prediabetes remission without weight loss protects against incident diabetes via improved insulin sensitivity.
Why the study?
Does achieving prediabetes remission without weight loss prevent incident type 2 diabetes in individuals with prediabetes?
Population
Individuals with prediabetes from the multicenter Prediabetes Lifestyle Intervention Study and the US…
Comparison
Achieving prediabetes remission without weight… vs Nonresponders.
Design
Cohort
Authors
Loading...
Achieving glycemic targets for prediabetes remission protects against type 2 diabetes even in the absence of weight loss, suggesting guidelines should emphasize glycemic goals alongside weight loss.
RCT
randomized
Yes
Does achieving prediabetes remission without weight loss prevent incident type 2 diabetes in individuals with prediabetes?
Achieving glycemic targets for prediabetes remission protects against type 2 diabetes even in the absence of weight loss, suggesting guidelines should emphasize glycemic goals alongside weight loss.
Sandforth et al. (2025) conducted an RCT in Prediabetes. Prediabetes remission vs. Nonresponders was evaluated on Incident type 2 diabetes. Achieving prediabetes remission without weight loss protects against incident type 2 diabetes through improved insulin sensitivity and subcutaneous rather than visceral fat accumulation.