Association of endometriosis with hematuria markers: A Mendelian randomization study

Identification of appropriate biomarkers is of great clinical significance for early diagnosis of endometriosis (EMs). This study aimed to comprehensively analyze the association between EMs and blood and urine biomarkers (BUB). Candidate EMs-related single nucleotide polymorphisms were obtained from recent genome-wide association studies. The UK Biobank cohort included 3,63,228 participants with BUB test data to calculate the polygenic risk score for EMs. Two-way, 2-sample Mendelian randomization (MR) was used to assess the potential relationship between candidate BUB and EMs. We found a significant association between EMs and triglycerides and calcium in both forward and reverse MR ( r > 1, P < .05). In the positive MR analysis, we also found that insulin-like growth factor-1 was a risk factor for EMs, and high-density lipoprotein was a protective factor for EMs. Our findings provide insights into the role of BUB in the early detection and treatment of EMs.