What question did this study set out to answer?

The aim is to investigate how spermidine affects oxidative stress and microbiota in response to high copper diets.

February 23, 2026Free Radical Research0 citations

Spermidine improve high copper diet -induced intestinal oxidative stress and microbiota community composition

YQYuxin QiSichuan Agricultural University DJDongmei JiangSichuan Agricultural University SLShuo LiSichuan Agricultural University

Key Points

The aim is to investigate how spermidine affects oxidative stress and microbiota in response to high copper diets.
Experimental design examining the impact of spermidine on high copper diet subjects
Assessment of intestinal oxidative stress levels and microbiota composition
Evaluation of antioxidant markers and immune function
Spermidine supplementation reduces oxidative stress levels
Alters microbiota composition by enhancing Lachnospiraceae
Boosts immune function markers such as IgA

Abstract

These findings suggest that spermidine supplementation restores intestinal architecture, boosts beneficial microbiota (e. g. , Firmicutes, unclassifiedfLachnospiraceae), and enhances antioxidant markers (SOD, T-AOC) and immune function (IgA).

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