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February 23, 2026Journal of NanobiotechnologyOpen Access

A stimuli-responsive mitochondria-targeted nanoplatform for glioblastoma therapy: modulating the blood-brain barrier and delivering precise chemotherapy

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Authors

WLWeihong LuoFZFENGTIAN ZHANGKWKang Wang

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Overview

This novel nanoplatform utilizing celastrol improves apoptosis in glioblastoma by enhancing blood-brain barrier function and suggesting new therapeutic strategies.

Key Points

  • This research aims to develop a mitochondria-targeted nanoplatform for enhanced glioblastoma therapy through blood-brain barrier modulation.
  • Developed a stimuli-responsive nanoplatform (Cela@Lip-IRH) encapsulating celastrol.
  • Investigated the cellular uptake and mitochondrial co-localization in BBB and GBM cells in vitro.
  • Assessed BBB penetration and specific accumulation of the nanoplatform in GBM tumors in vivo.
  • Cela@Lip-IRH promoted enhanced apoptosis in glioblastoma cells.
  • Demonstrated significant improvement in blood-brain barrier integrity.
  • Provided insights into novel therapeutic strategies for treating neurological disorders.

Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/699ba07072792ae9fd87008dhttps://doi.org/10.1186/s12951-026-04206-7
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