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February 23, 2026Annals of the American Thoracic Society

BMI-Related Genetic Factors and COPD Imaging Phenotypes

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Authors

JZJingzhou ZhangMMMatthew MollCDCatherine L. Debban

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Overview

Observational study finds that higher BMI polygenic risk is linked to reduced emphysema and increased airway wall thickening in COPD patients.

Key Points

  • To explore the relationship between BMI-related genetic factors and COPD imaging phenotypes.
  • Conducted observational analysis in individuals with and without COPD.
  • Evaluated associations between BMI polygenic risk and imaging phenotypes.
  • Assessed quantitative and visual measures of emphysema and airway wall thickness (AWT).
  • Higher BMI polygenic risk correlates with decreased emphysema quantitatively and visually.
  • Increased airway wall thickening observed with higher genetic risk levels.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/699ba09772792ae9fd8706bfhttps://doi.org/10.1093/annalsats/aaoag007
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