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This is a Meta-Analysis study (also classified as: Systematic Review).

February 23, 2026EClinicalMedicineOpen Access

Effect of psychotropic medications on suicide-related outcomes: a systematic review and meta-analysis of observational studies

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This research aims to assess the effects of psychotropic medications on suicide-related outcomes in individuals with psychiatric disorders.
Conducted a systematic review and meta-analysis of observational studies.
Analyzed data from 48 independent studies across 13 countries.
Included studies focused on suicide-related outcomes in adults treated with psychotropic medications.
Second-generation antipsychotics associated with reduced suicide mortality, notably clozapine and olanzapine.
Lithium and valproic acid demonstrated lower suicide risks in bipolar disorder.
SSRIs and tricyclic antidepressants linked to lower suicide mortality risks in depression.

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Systematic review reveals psychotropic medications affect suicide risks in psychiatric conditions, highlighting the significance of treatment choice.

Kozhevnikova et al. (2026) studied this question.

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Systematic review reveals psychotropic medications affect suicide risks in psychiatric conditions, highlighting the significance of treatment choice.